We investigate the properties of pseudoscalar D and vector D* mesons in an isospin asymmetric nuclear medium using a hybrid approach that integrates the light-front quark model with the chiral SU(3) quark mean field model. The influence of isospin asymmetric nuclear medium is examined by utilizing the in-medium quark masses derived from the chiral SU(3) quark mean field model as an input in the light-front quark model to study the medium modification of D mesons. We examine the impact of isospin asymmetry and baryon density at zero and finite temperature on the effective masses, weak decay constants, and distribution amplitudes of the pseudoscalar mesons D0, D+, D_s, and the vector mesons D0*, D+*, and D_s*. Our results indicate significant medium-induced changes for pseudoscalar D and vector D* mesons having u/d as one of their constituent quarks, while a comparatively reduced effect is observed for mesons containing a strange quark. In contrast to temperature and isospin asymmetry, changes in the baryon density of the nuclear medium have a larger effect on different properties of D and D* mesons.